the Hekimi Lab: Publications
Haynes CM, Hekimi S. (2022)
Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans. Genetics.
Branicky R, Wang Y, Khaki A, Liu J, Kramer-Drauberg M, Hekimi S. (2022)
Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression. Science Advances 8(48): eadc9851.
Rebelo A, Tomaselli P, Medina J, Nyvltova E, Ruiz A, Dohrn M, Wang Y, Saporta M, Hekimi S, Barrientos A, Weihl C, Shy M, Marques W, Zuchner S. (2022)
Biallelic variants in COQ7 leading to coenzyme Q10 deficiency cause charcot-marie-tooth disease. Journal Of The Peripheral Nervous System. S118-S118.
Wang Y, Gumus E, Hekimi S. (2022)
A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options. Molecular Genetics and Metabolism Reports 31:100877.
Wang Y, Hekimi S. (2022)
The CoQ biosynthetic di-iron carboxylate hydroxylase COQ7 is inhibited by in vivo metalation with manganese but remains function by metalation with cobalt. MicroPubl Biol.
Wang Y, Hekimi S. (2022)
The efficacy of coenzyme Q10 treatment in alleviating the symptoms of primary coenzyme Q10 deficiency: a systematic review. J Cell Mol Med. 26: 4635-4644.
Wang Y, Hekimi S. (2021)
Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells. Cell Death Discov. 7(1):201.
Rossmann M., Hoi K., Chan V. Abraham B., Yang S., Mullahoo J., Papanastasiou M., Wang Y., Elia I., Perlin J., Hagedorn E., Hetzel S., Weigert R., Vyas S., Nag P., Sullivan L., Warren C., Dorjsuren B., Greig E., Adatto I., Cowan C., Schreiber S., Young R., Meissner A., Haigis M., Hekimi S., Carr S., Zon L. (2021)
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science. 372(6543):716-721.
Wang Y, Hekimi S. (2020)
Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations. Redox Biol. 36:101680.
Kramer-Drauberg M, Liu JL, Desjardins D, Wang Y, Branicky R, Hekimi S. (2020)
ROS regulation of RAS and vulva development in Caenorhabditis elegans. PLoS Genet. 16(6):e1008838.
Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM. (2020)
SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis. 11(4):263. Wang Y, Hekimi S. (2019) The Complexity of Making Ubiquinone. Trends Endocrinol Metab. 30(12):929-943.
Wang Y, Branicky R, Noë A, Hekimi S. (2018)
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling. J Cell Biol. 217(6):1915-1928.
Hughes BG, Harrison PM, Hekimi S. (2017)
Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data. Sci Rep. 7(1):17744.
Hughes BG, Hekimi S. (2017)
Many possible maximum lifespan trajectories. Nature. 546(7660):E8-E9.
Branicky R, Hekimi S. (2017)
Proteostasis or Aging: Let the CHIPs Fall Where They May. Dev Cell. 41(2):126-128.
Wang Y, Smith C, Parboosingh JS, Khan A, Innes M, Hekimi S. (2017)
Pathogenicity of two COQ7 mutations and responses to 2,4-dihydroxybenzoate bypass treatment. J Cell Mol Med. 21(10):2329-2343.
Liu JL, Yee C, Wang Y, Hekimi S. (2017)
A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1. Sci Rep. 7(1):859.
Branicky R, Hekimi S. (2017)
Making a splash with splicing. Cell Res. 27(4):457-458.
Blanchette CR, Thackeray A, Perrat PN, Hekimi S, Bénard CY. (2017)
Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans. PLoS Genet. 13(1):e1006525.
Hekimi S, Wang Y, Noë A. (2016)
Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers! Front Genet. 7:161.
Desjardins D, Cacho-Valadez B, Liu JL, Wang Y, Yee C, Bernard K, Khaki A, Breton L, Hekimi S. (2017)
Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell. 16(1):104-112.
Hughes BG, Hekimi S. (2016)
Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates. Genetics. 204(3):905-920.
Wang Y, Hekimi S. (2016)
Understanding Ubiquinone. Trends Cell Biol. 26(5):367-378.
Wang Y, Hekimi S. (2015)
Mitochondrial dysfunction and longevity in animals: Untangling the knot. Science. 350(6265):1204-7.
Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A. (2015)
Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 14(5):887-95.
Wang Y, Oxer D, Hekimi S. (2015)
Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis. Nat Commun. 6:6393.
Song P, Zhang W, Sobolevski A, Bernard K, Hekimi S, Liu X. (2015)
A microfluidic device for efficient chemical testing using Caenorhabditis elegans. Biomed Microdevices. 17(2):38.
Schaar CE, Dues DJ, Spielbauer KK, Machiela E, Cooper JF, Senchuk M, Hekimi S, Van Raamsdonk JM. (2015)
Mitochondrial and cytoplasmic ROS have opposing effects on lifespan. PLoS Genet. 11(2):e1004972.
Lapointe J, Hughes BG, Bigras E, Hekimi S. (2014)
Compensatory elevation of voluntary activity in mouse mutants with impaired mitochondrial energy metabolism. Physiol Rep. 2(11):e12214.
Yee C, Yang W, Hekimi S. (2014)
The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell. 157(4):897-909.
Baruah A, Chang H, Hall M, Yuan J, Gordon S, Johnson E, Shtessel LL, Yee C, Hekimi S, Derry WB, Lee SS. (2014)
CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants. PLoS Genet. 10(2):e1004097.
Liu JL, Hekimi S. (2013)
The impact of mitochondrial oxidative stress on bile acid-like molecules in C. elegans provides a new perspective on human metabolic diseases. Worm. 2(1):e21457.
Wang Y, Hekimi S. (2013)
Mitochondrial respiration without ubiquinone biosynthesis. Hum Mol Genet. 22(23):4768-83.
Hekimi S. (2013)
Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress. Oncoimmunology. 2(4):e23793.
Wang Y, Hekimi S. (2013)
Molecular genetics of ubiquinone biosynthesis in animals. Crit Rev Biochem Mol Biol. 48(1):69-88.
Wang D, Wang Y, Argyriou C, Carrière A, Malo D, Hekimi S. (2012)
An enhanced immune response of Mclk1⁺/⁻ mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging. PLoS One. 7(11):e49606.
Lapointe J, Wang Y, Bigras E, Hekimi S. (2012)
The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice. J Cell Biol. 199(2):215-24.
Van Raamsdonk JM, Hekimi S. (2012)
Superoxide dismutase is dispensable for normal animal lifespan. Proc Natl Acad Sci U S A. 109(15):5785-90.
Liu JL, Desjardins D, Branicky R, Agellon LB, Hekimi S. (2012)
Mitochondrial oxidative stress alters a pathway in Caenorhabditis elegans strongly resembling that of bile acid biosynthesis and secretion in vertebrates. PLoS Genet. 8(3):e1002553.
Robert F, Mills JR, Agenor A, Wang D, DiMarco S, Cencic R, Tremblay ML, Gallouzi IE, Hekimi S, Wing SS, Pelletier J. (2012)
Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival. Cancer Res. 72(3):747-56.
Hughes BG, Hekimi S. (2011)
A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice. PLoS One. 6(10):e26116.
Van Raamsdonk JM, Hekimi S. (2011)
FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1. Mech Ageing Dev. 132(10):519-21.
Hekimi S, Lapointe J, Wen Y. (2011)
Taking a "good" look at free radicals in the aging process. Trends Cell Biol. 21(10):569-76.
Hekimi S, Hughes B. (2011)
Phylogenetic ubiquity of the effects of altered ubiquinone biosynthesis on survival. Aging (Albany NY). 3(3):184-5.
Yang W, Hekimi S. (2010)
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol. 8(12):e1000556.
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS. (2010)
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. Am J Respir Crit Care Med. 183(8):1043-54.
Van Raamsdonk JM, Hekimi S. (2010)
Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship? Antioxid Redox Signal. 13(12):1911-53.
Van Raamsdonk JM, Meng Y, Camp D, Yang W, Jia X, Bénard C, Hekimi S. (2010)
Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage. Genetics. 185(2):559-71.
Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM Jr, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. (2010)
Impact papers on aging in 2009. Aging (Albany NY). 2(3):111-21.
Yang W, Hekimi S. (2010)
Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell. 9(3):433-47.
Zheng H, Lapointe J, Hekimi S. (2010)
Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1(+/)(-) mutants. Exp Neurol. 223(2):557-65.
Branicky R, Desjardins D, Liu JL, Hekimi S. (2010)
Lipid transport and signaling in Caenorhabditis elegans. Dev Dyn. 239(5):1365-77.
Wang D, Malo D, Hekimi S. (2010)
Elevated mitochondrial reactive oxygen species generation affects the immune response via hypoxia-inducible factor-1alpha in long-lived Mclk1+/- mouse mutants. J Immunol. 184(2):582-90.
Lapointe J, Hekimi S. (2010)
When a theory of aging ages badly. Cell Mol Life Sci. 67(1):1-8.
Lapointe J, Stepanyan Z, Bigras E, Hekimi S. (2009)
Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice. J Biol Chem. 284(30):20364-74.
Hughes BG, Hekimi S. (2009)
Mclk1+/- mice are not resistant to the development of atherosclerosis. Lipids Health Dis. 8:16.
Van Raamsdonk JM, Hekimi S. (2009)
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361.
Wang Y, Branicky R, Stepanyan Z, Carroll M, Guimond MP, Hihi A, Hayes S, McBride K, Hekimi S. (2009)
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. J Biol Chem. 284(1):314-23.
Lapointe J, Hekimi S. (2008)
Early mitochondrial dysfunction in long-lived Mclk1+/- mice. J Biol Chem. 283(38):26217-27.
Yang W, Li J, Hekimi S. (2007)
A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long- lived mitochondrial mutants of Caenorhabditis elegans. Genetics. 177(4):2063-74.
Hihi AK, Beauchamp MC, Branicky R, Desjardins A, Casanova I, Guimond MP, Carroll M, Ethier M, Kianicka I, McBride K, Hekimi S. (2008)
Evolutionary conservation of drug action on lipoprotein metabolism-related targets. J Lipid Res. 49(1):74-83.
Hekimi S. (2006)
How genetic analysis tests theories of animal aging. Nat Genet. 38(9):985-91.
Branicky R, Hekimi S. (2006)
What keeps C. elegans regular: the genetics of defecation. Trends Genet. 22(10):571-9.
Stepanyan Z, Hughes B, Cliche DO, Camp D, Hekimi S. (2006)
Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging. Exp Gerontol. 41(10):940-51.
Seitan VC, Banks P, Laval S, Majid NA, Dorsett D, Rana A, Smith J, Bateman A, Krpic S, Hostert A, Rollins RA, Erdjument-Bromage H, Tempst P, Benard CY, Hekimi S, Newbury SF, Strachan T. (2006)
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. PLoS Biol. 4(8):e242.
Carrière A, Liu X, Hekimi S. (2006)
The age of heterozygosity. Age (Dordr). 28(2):201-8.
Branicky R, Nguyen PA, Hekimi S. (2006)
Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans. Mol Cell Biol. 26(10):3976-85.
Branicky R, Hekimi S. (2005)
Specification of muscle neurotransmitter sensitivity by a Paired-like homeodomain protein in Caenorhabditis elegans. Development. 132(22):4999-5009.
Liu X, Jiang N, Hughes B, Bigras E, Shoubridge E, Hekimi S. (2005)
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev. 19(20):2424-34.
Bénard CY, Kébir H, Takagi S, Hekimi S. (2004)
mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans. Development. 131(23):5947-58.
de Jong L, Meng Y, Dent J, Hekimi S. (2004)
Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics. 168(2):845-54.
Shibata Y, Branicky R, Landaverde IO, Hekimi S. (2003)
Redox regulation of germline and vulval development in Caenorhabditis elegans. Science. 302(5651):1779-82.
Burgess J, Hihi AK, Benard CY, Branicky R, Hekimi S. (2003)
Molecular mechanism of maternal rescue in the clk-1 mutants of Caenorhabditis elegans. J Biol Chem. 278(49):49555-62.
Hihi AK, Kebir H, Hekimi S. (2003)
Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes. J Biol Chem. 278(42):41013-8.
Jiang N, Bénard CY, Kébir H, Shoubridge EA, Hekimi S. (2003)
Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. J Biol Chem. 278(24):21678-84.
Hekimi S, Guarente L. (2003)
Genetics and the specificity of the aging process. Science. 299(5611):1351-4.
Bénard C, Hekimi S. (2002)
Long-lived mutants, the rate of aging, telomeres and the germline in Caenorhabditis elegans. Mech Ageing Dev. 123(8):869-80.
Miyadera H, Kano K, Miyoshi H, Ishii N, Hekimi S, Kita K. (2002)
Quinones in long-lived clk-1 mutants of Caenorhabditis elegans. FEBS Lett. 512(1-3):33-7.
Branicky R, Shibata Y, Feng J, Hekimi S. (2001)
Phenotypic and suppressor analysis of defecation in clk-1 mutants reveals that reaction to changes in temperature is an active process in Caenorhabditis elegans. Genetics. 159(3):997-1006.
Hekimi S, Burgess J, Bussière F, Meng Y, Bénard C. (2001)
Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity. Trends Genet. 17(12):712-8.
Feng J, Bussière F, Hekimi S. (2001)
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell. 1(5):633-44.
Hihi AK, Gao Y, Hekimi S. (2001)
Ubiquinone is necessary for Caenorhabditis elegans development at mitochondrial and non-mitochondrial sites. J Biol Chem. 277(3):2202-6.
Bénard C, McCright B, Zhang Y, Felkai S, Lakowski B, Hekimi S. (2001)
The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development. 128(20):4045-55.
Levavasseur F, Miyadera H, Sirois J, Tremblay ML, Kita K, Shoubridge E, Hekimi S. (2001)
Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration. J Biol Chem. 276(49):46160-4.
Lemieux J, Lakowski B, Webb A, Meng Y, Ubach A, Bussière F, Barnes T, Hekimi S. (2001)
Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria. Genetics. 159(1):147-57.
Jiang N, Levavasseur F, McCright B, Shoubridge EA, Hekimi S. (2001)
Mouse CLK-1 is imported into mitochondria by an unusual process that requires a leader sequence but no membrane potential. J Biol Chem. 276(31):29218-25.
Hekimi S, Bénard C, Branicky R, Burgess J, Hihi AK, Rea S. (2001)
Why only time will tell. Mech Ageing Dev. 122(7):571-94.
Miyadera H, Amino H, Hiraishi A, Taka H, Murayama K, Miyoshi H, Sakamoto K, Ishii N, Hekimi S, Kita K. (2001)
Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. J Biol Chem. 276(11):7713-6.
Labbé JC, Burgess J, Rokeach LA, Hekimi S. (2000)
ROP-1, an RNA quality-control pathway component, affects Caenorhabditis elegans dauer formation. Proc Natl Acad Sci U S A. 97(24):13233-8.
Hekimi S. (2000)
Crossroads of aging in the nematode Caenorhabditis elegans. Results Probl Cell Differ. 29:81-112.
Branicky R, Bénard C, Hekimi S. (2000)
clk-1, mitochondria, and physiological rates. Bioessays. 22(1):48-56.
Labbé JC, Hekimi S, Rokeach LA. (1999)
Assessing the function of the Ro ribonucleoprotein complex using Caenorhabditis elegans as a biological tool. Biochem Cell Biol. 77(4):349-54.
Whitfield CW, Bénard C, Barnes T, Hekimi S, Kim SK. (1999)
Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol Biol Cell. 10(6):2087-100.
Felkai S, Ewbank JJ, Lemieux J, Labbé JC, Brown GG, Hekimi S. (1999)
CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J. 18(7):1783-92.
Labbé JC, Hekimi S, Rokeach LA. (1999)
The levels of the RoRNP-associated Y RNA are dependent upon the presence of ROP-1, the Caenorhabditis elegans Ro60 protein. Genetics. 151(1):143-50.
Lakowski B, Hekimi S. (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 95(22):13091-6.
Phelan P, Bacon JP, Davies JA, Stebbings LA, Todman MG, Avery L, Baines RA, Barnes TM, Ford C, Hekimi S, Lee R, Shaw JE, Starich TA, Curtin KD, Sun YA, Wyman RJ. (1998)
Innexins: a family of invertebrate gap-junction proteins. Trends Genet. 14(9):348-9.
Hekimi S, Lakowski B, Barnes TM, Ewbank JJ. (1998)
Molecular genetics of life span in C. elegans: how much does it teach us? Trends Genet.14(1):14-20.
Barnes TM, Hekimi S. (1997)
The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. J Neurochem. 69(6):2251-60.
Takagi S, Bénard C, Pak J, Livingstone D, Hekimi S. (1997)
Cellular and axonal migrations are misguided along both body axes in the maternal-effect mau-2 mutants of Caenorhabditis elegans. Development. 124(24):5115-26.
Ogura K, Shirakawa M, Barnes TM, Hekimi S, Ohshima Y. (1997)
The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51. Genes Dev. 11(14):1801-11.
Ewbank JJ, Barnes TM, Lakowski B, Lussier M, Bussey H, Hekimi S. (1997)
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science. 275(5302):980-3.
Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S. (1996)
The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neurochem. 67(1):46-57.
Lakowski B, Hekimi S. (1996)
Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272(5264):1010-3.
Hekimi S, Boutis P, Lakowski B. (1995)
Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans. Genetics. 141(4):1351-64.
Barnes TM, Kohara Y, Coulson A, Hekimi S. (1995)
Meiotic recombination, noncoding DNA and genomic organization in Caenorhabditis elegans. Genetics. 141(1):159-79.
Wong A, Boutis P, Hekimi S. (1995)
Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics. 139(3):1247-59.
Hekimi S, Kershaw D. (1993)
Axonal guidance defects in a Caenorhabditis elegans mutant reveal cell-extrinsic determinants of neuronal morphology. J Neurosci. 13(10):4254-71.
Hosono R, Hekimi S, Kamiya Y, Sassa T, Murakami S, Nishiwaki K, Miwa J, Taketo A, Kodaira KI. (1992)
The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans. J Neurochem. 58(4):1517-25.
Hekimi S, Fischer-Lougheed J, O'Shea M. (1991)
Regulation of neuropeptide stoichiometry in neurosecretory cells. J Neurosci. 11(10):3246-56.
Hekimi S. (1990)
A neuron-specific antigen in C. elegans allows visualization of the entire nervous system. Neuron. 4(6):855-65.
Hekimi S, Burkhart W, Moyer M, Fowler E, O'Shea M. (1989)
Dimer structure of a neuropeptide precursor established: consequences for processing. Neuron. 2(4):1363-8.
Hekimi S, O'Shea M. (1989)
Biosynthesis of adipokinetic hormones (AKHs): further characterization of precursors and identification of novel products of processing. J Neurosci. 9(3):996-1003.
Hekimi S, O'Shea M. (1987)
Identification and purification of two precursors of the insect neuropeptide adipokinetic hormone. J Neurosci. 7(9):2773-84.