the Hekimi LAB

The Hekimi Lab: Inivited Reviews

Wang Y, Hekimi S (2019) 

The complexity of making ubiquinone.Trends in Endocrinology and Metabolism, 30(12):929-943.

Wang Y, Branicky R, Noë A, Hekimi S (2018) 

Superoxide dismutases: dual roles in controlling ROS damage and regulating ROS signaling. J. Cell Biology, doi: 10.1083/jcb.201708007. 

Hekimi S, Wang Y, Noe A (2016)

Mitochondrial ROS and the effectors of the intrinsic apoptotic pathway in aging cells: the discerning killers. Frontiers in Genetics. doi: 10.3389/fgene.2016.0016.

Ying Wang and Siegfried Hekimi (2016)
"Understanding Ubiquinone" Trends Cell Biol. 2016 Jan 27. pii: S0962-8924(16)00003-9.

Ying Wang and Siegfried Hekimi (2015)

Mitochondrial dysfunction and longevity in animals: Untangling the knot Science 4 December 2015: 350 (6265), 1204-1207. [DOI:10.1126/science.aac4357]

Hekimi S (2013)
Enhanced immunity in slowly-aging mutant mice with high mitochondrial oxidative stress. OncoImmunology, Apr 1;2(4):e23793.

Wang Y, Hekimi S (2012)
Molecular genetics of ubiquinone biosynthesis in animals. Critical Reviews in Biochemistry and Molecular Biology, 48:69-88.

Liu J-L, Hekimi S (2012)
The impact of mitochondrial oxidative stress on bile acid- like molecules in C. elegans provides a new perspective on human metabolic diseases. Worm, in Press.

Hekimi S, Lapointe J, Yang W (2011)
Taking a ‘Good’ Look at ROS in the Aging Process. Trends in Cell Biology, (10):569-76.

Van Raamsdonk, Hekimi S (2010)
Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship? Antioxidants & Redox Signalling, 13(12):1911-53.

Branicky R, Desjardins D, Liu J, Hekimi S (2010)
Lipid transport and signalling in Caenorhabditis elegans. Developmental Dynamics, May;239(5):1365-77.

Lapointe J, Hekimi S (2010)
When an aging theory ages badly. Cellular and Molecular Life Sciences, Jan;67(1):1-8.

Hekimi, S (2006)
How genetic analysis tests theories of animal aging. Nature Genetics, 38(9):985-91.

Stepanyan Z, Hughes B, Cliche D, Camp D, Hekimi S (2006)
Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging. Experimental Gerontology, 41(10):940-51.

Branicky R, Hekimi S (2006)
What keeps C. elegans regular: the genetics of defecation. Trends in Genetics, 22(10):571-9.

Carrière A, Liu, XX, Hekimi S (2006)
The age of heterozygosity. AGE, 28(2): 201-208.

Hekimi S, Guarente L (2003)
Genetics and the specificity of the aging process. Science, 299(5611):1351-4.

Bénard C, Hekimi S (2002)

Long-lived mutants, the rate of aging, telomeres and the germline in Caenorhabditis elegans. Mech Ageing Dev, 123(8): 869-80.

Miyadera H, Kano K, Miyoshi H, Ishii N, Hekimi S, and Kita K (2002)
Quinones in long-lived clk-1 mutants of C. elegans. FEBS Letters, 512:33-7.

Hekimi S, Burgess J, Bussière F, Bénard C, Meng Y (2001)
Molecular Genetics of Life Span in C. elegans: Molecular diversity, physiological complexity, mechanistic simplicity. Trends in Genetics, 17(12): 712-8.

Hekimi S, Bénard C, Branicky R, Burgess J, Hihi A, Rea S (2001) 

Why Only Time Will Tell Mech Ageing Dev, 122:571-94.

Branicky R, Bénard C, Hekimi S (2000)
clk-1, Mitochondria and Physiological Rates. BioEssays, 22: 48-56.

Labbé J-C, Hekimi S, Rokeach L (1999)
Assessing the function of the Ro RNP complex using Caenorhabditis elegans as a biological tool. Biochem Cell Biol, 77:349-354.

Phelan P, Bacon JP, Davies JA, Stebbings LA, Todman MG, Avery L, Baines RA, Barnes TM, Ford C, Hekimi S, Lee R, Shaw JE, Starich TA, Curtin KD, Sun YA, Wyman RJ (1998)
Innexins: a family of invertebrate gap-junction proteins. Trends in Genetics, 14(9):348-9

Hekimi S, Lakowski B, Barnes T, Ewbank J (1998)
Molecular genetics of life span in C. elegans: how much does it teach us? Trends in Genetics, 14(1):14-20.

Hekimi S (1997)

Une horloge cellulaire et physiologique règle la vie du nématode Caenorhabditis elegans. Médecine/Science, 13(4):472-482.