the Hekimi LAB

the Hekimi LAB

The Hekimi Lab: Inivited Reviews

1. Hekimi S (1997)

Une horloge cellulaire et physiologique règle la vie du nématode Caenorhabditis elegans. Médecine/Science, 13(4):472-482.

2. Hekimi S, Lakowski B, Barnes T, Ewbank J (1998)
Molecular genetics of life span in C. elegans: how much does it teach us? Trends in Genetics, 14(1):14-20.

3. Phelan P, Bacon JP, Davies JA, Stebbings LA, Todman MG, Avery L, Baines RA, Barnes TM, Ford C, Hekimi S, Lee R, Shaw JE, Starich TA, Curtin KD, Sun YA, Wyman RJ (1998)
Innexins: a family of invertebrate gap-junction proteins. Trends in Genetics, 14(9):348-9

4. Labbé J-C, Hekimi S, Rokeach L (1999)
Assessing the function of the Ro RNP complex using Caenorhabditis elegans as a biological tool. Biochem Cell Biol, 77:349-354.

5. Branicky R, Bénard C, Hekimi S (2000)
clk-1, Mitochondria and Physiological Rates. BioEssays, 22: 48-56.

6. Hekimi S, Bénard C, Branicky R, Burgess J, Hihi A, Rea S (2001) 

Why Only Time Will Tell Mech Ageing Dev, 122:571-94.

7. Hekimi S, Burgess J, Bussière F, Bénard C, Meng Y (2001)
Molecular Genetics of Life Span in C. elegans: Molecular diversity, physiological complexity, mechanistic simplicity. Trends in Genetics, 17(12): 712-8.

8. Miyadera H, Kano K, Miyoshi H, Ishii N, Hekimi S, and Kita K (2002)
Quinones in long-lived clk-1 mutants of C. elegans. FEBS Letters, 512:33-7.

9. Bénard C, Hekimi S (2002)
Long-lived mutants, the rate of aging, telomeres and the germline in Caenorhabditis elegans. Mech Ageing Dev, 123(8): 869-80.

10. Hekimi S, Guarente L (2003)
Genetics and the specificity of the aging process. Science, 299(5611):1351-4.

11. Carrière A, Liu, XX, Hekimi S (2006)
The age of heterozygosity. AGE, 28(2): 201-208.

12. Branicky R, Hekimi S (2006)
What keeps C. elegans regular: the genetics of defecation. Trends in Genetics, 22(10):571-9.

13. Stepanyan Z, Hughes B, Cliche D, Camp D, Hekimi S (2006)
Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging. Experimental Gerontology, 41(10):940-51.

14. Hekimi, S (2006)
How genetic analysis tests theories of animal aging. Nature Genetics, 38(9):985-91.

15. Lapointe J, Hekimi S (2010)
When an aging theory ages badly. Cellular and Molecular Life Sciences, Jan;67(1):1-8.

16. Branicky R, Desjardins D, Liu J, Hekimi S (2010)
Lipid transport and signalling in Caenorhabditis elegans. Developmental Dynamics, May;239(5):1365-77.

17. Van Raamsdonk, Hekimi S (2010)
Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship? Antioxidants & Redox Signalling, 13(12):1911-53.

18. Hekimi S, Lapointe J, Yang W (2011)
Taking a ‘Good’ Look at ROS in the Aging Process. Trends in Cell Biology, (10):569-76.

19. Liu J-L, Hekimi S (2012)
The impact of mitochondrial oxidative stress on bile acid- like molecules in C. elegans provides a new perspective on human metabolic diseases. Worm, in Press.

20. Wang Y, Hekimi S (2012)
Molecular genetics of ubiquinone biosynthesis in animals. Critical Reviews in Biochemistry and Molecular Biology, 48:69-88.

21. Hekimi S (2013)
Enhanced immunity in slowly-aging mutant mice with high mitochondrial oxidative stress. OncoImmunology, Apr 1;2(4):e23793.

22. Ying Wang and Siegfried Hekimi (2015)

Mitochondrial dysfunction and longevity in animals: Untangling the knot Science 4 December 2015: 350 (6265), 1204-1207. [DOI:10.1126/science.aac4357]

23. Ying Wang and Siegfried Hekimi (2016)
"Understanding Ubiquinone" Trends Cell Biol. 2016 Jan 27. pii: S0962-8924(16)00003-9.