the Hekimi LAB

the Hekimi LAB

Siegfried Hekimi was born in Zürich and obtained his undergraduate degree in Biology at the University of Geneva. He then moved to the famed Laboratory of Molecular Biology (LMB) of the Medical Research Council in Cambridge, UK, to collaborate with Dr J.G. White as a post-doctoral fellow of the Swiss National Science Fund. It is at the LMB where Hekimi developed his interest for using 'the worm' for translational studies in the biology of aging. It is also in Cambridge that he identified the first mutants that helped to demonstrate that aging could be manipulated genetically and that inducing mild mitochondrial dysfunction could in fact slow down the aging process of animals. In 1992 he joined McGill University where he has been a full professor since 2004.

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Photo Album of Dr. Hekimi's Cycling Career




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We are using mutants of the microscopic worm Caenorhabditis elegans and the mouse  to study aging, a crucial, profound, and poorly understood biological phenomenon. We hope our insights will provide new ways for medical intervention on the aging process. We are particularly focusing on gene activities that affect mitochondrial function, and on mutants that enhance longevity. We are also interested in the biosynthesis and function of ubiquinone (UQ, Coenzyme Q, CoQ), the obligate, diffusible, relay in the mitochondrial electron transport chain. Here too we use mutants in both organisms to unravel the basic biochemical functions of ubiquinone and to develop drugs that can help alleviate the diseases linked to ubiquinone deficiency.






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Hughes B, Hekimi S (2016)
Different mechanisms of longevity in long-lived mouse and Caenorhabditis mutants revealed by statistical analysis of mortality rates. Genetics, 204, 905-920.

Wang Y, Smith V, Parboosingh J, Khan S, Innes M, Hekimi S (2017)
Characterization of COQ7 mutations from two very different patients identifies treatment options and exclusions.
J Cellular and Molecular Medicine,

Liu JL, Yee C, Wang Y, Hekimi S (2017)
A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1. Scientific Reports, 7(1):859.

Hughes B, Hekimi S (2017)
Many possible maximum lifespan trajectories.
Nature, 28;546(7660):E8-E9.





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The Lab

The laboratory is located in two buildings. The Stewart Biological Sciences Building is located on the North-East corner of Docteur Penfield Avenue and William Osler Street in the west part of the McGill campus. It is near the metro station Peel Map The Francesco Bellini Life Sciences Building accommodates scientists from biology, biochemistry and physiology.

Contact


Dr. Hekimi: siegfried.hekimi@mcgill.ca

     @SiegfriedHekimi

Lab Manager: eve.bigras@mcgill.ca


Department of Biology, McGill University 


Stewart Building

1205 Avenue Docteur Penfield 

Montréal, Québec, H3A 1B1


Bellini Building

3649 Promenade Sir William Osler 

Montreal, Quebec H3G 0B1